The personal statement is a critical component of your AMCAS application.  It gives you a blank canvas and the creative freedom to tell the admission committee member more about yourself.  The personal statement should convey personal qualities and traits that you possess and would be highly desirable to next year's incoming medical school class.

• Leadership: Write about your work setting up a fund raiser for a relief organization, your work teaching students in taekwondo, or your involvement as the student volunteer coordinator at the hospital.
• Real world experience: Have you worked at a company before you apply to medical school?  What kind of experiences could you bring to the incoming class.
• Curiosity: Made an interesting, serendipitous discovery in the lab?  You can write briefly about the discovery and its impact but don't dwell on it too much.  Focus not on the research findings itself, but on how you seek answers beyond the textbook answers.
• Perseverance: Taking a graduate level course and having to constantly talk to the professor to convince him to let you into the course and how the course has affected/reinforced your decision to pursue medicine.